Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation

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Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation.

Increased leptin levels have been suggested to contribute to cardiac hypertrophy and attenuate cardiac lipid accumulation in obesity, although it has been difficult to separate leptin's direct effects from those caused by changes in body weight and adiposity. To determine whether leptin attenuates cardiac lipid accumulation in obesity or directly causes left ventricular hypertrophy (LVH), we ge...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism

سال: 2014

ISSN: 0193-1849,1522-1555

DOI: 10.1152/ajpendo.00005.2014